Interferon-gamma (IFN-γ) is a pleiotropic molecule with associated antiproliferative, pro-
apoptotic and antitumor mechanisms. This effector cytokine, often considered as a major …

Over the last three decades, intravesical immunotherapy with the biological response
modifier Mycobacterium bovis bacillus Calmette–Guérin (BCG) has been established as the …

The interferon (IFN)‐γ component of the immune response plays an essential role in
combating infectious and non‐infectious diseases. Induction of IFN‐γ secretion by human T …

Human Immunodeficiency virus (HIV) enters the brain soon after seroconversion and
induces chronic neuroinflammation by infecting and activating brain macrophages …

In the past few decades, the indoleamine 2, 3 dioxygenase (IDO) subset of the kynurenine
(KYN) pathway of tryptophan (TRP) metabolism has been the subject of much research in …

One of the limitations for clinical applications of dendritic cell (DC)-based cancer
immunotherapy is the low potency in generating tumor antigen specific T cell responses. We …

miR-21 has been shown to regulate multiple mRNAs and cause tumor progression and
metastasis. However, whether miR-21-mediated posttranscriptional regulation is involved in …

Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades
governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) …

The oncolytic adenovirus (Ad) is currently being advanced as a promising antitumor remedy
as it selectively replicates in tumor cells and can transfer and amplify therapeutic genes …

The antitumor effect of IFN-α is mediated by the activation of CTLs, NK cells, and the
generation of highly potent Ag-presenting dendritic cells (IFN-DCs). In this study, we show …