Structural and functional insights into the spike protein mutations of emerging SARS-CoV-2 variants

D Gupta, P Sharma, M Singh, M Kumar… - Cellular and Molecular …, 2021 - Springer
Since the emergence of the first case of coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus (SARS-CoV-2), the viral genome has …

A review of human coronaviruses' receptors: the host-cell targets for the crown bearing viruses

A Nassar, IM Ibrahim, FG Amin, M Magdy, AM Elgharib… - Molecules, 2021 - mdpi.com
A novel human coronavirus prompted considerable worry at the end of the year 2019. Now,
it represents a significant global health and economic burden. The newly emerged …

The future of the COVID-19 pandemic: How good (or bad) can the SARS-CoV2 spike protein get?

MA Nugent - Cells, 2022 - mdpi.com
Severe acute respiratory syndrome virus 2 (SARS-CoV2) has infected an estimated 400
million people world-wide, causing approximately 6 million deaths from severe coronavirus …

Antigenic cross-reactivity between SARS-CoV-2 S1-RBD and its receptor ACE2

YC Lai, YW Cheng, CH Chao, YY Chang… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus
responsible for the ongoing COVID-19 pandemic. SARS-CoV-2 binds to the human cell …

How helpful were molecular dynamics simulations in shaping our understanding of SARS-CoV-2 spike protein dynamics?

JM Abduljalil, AM Elghareib, A Samir, AA Ezat… - International Journal of …, 2023 - Elsevier
The SARS-CoV-2 spike protein (S) represents an important viral component that is required
for successful viral infection in humans owing to its essential role in recognition of and entry …

Towards an optimal monoclonal antibody with higher binding affinity to the receptor-binding domain of SARS-CoV-2 spike proteins from different variants

A Neamtu, F Mocci, A Laaksonen… - Colloids and Surfaces B …, 2023 - Elsevier
A highly efficient and robust multiple scales in silico protocol, consisting of atomistic
Molecular Dynamics (MD), coarse-grain (CG) MD, and constant-pH CG Monte Carlo (MC) …

Cryogenic electron microscopy methodologies as analytical tools for the study of self-assembled pharmaceutics

N Koifman, Y Talmon - Pharmaceutics, 2021 - mdpi.com
Many pharmaceutics are aqueous dispersions of small or large molecules, often self-
assembled in complexes from a few to hundreds of molecules. In many cases, the …

Implications of the Immune Polymorphisms of the Host and the Genetic Variability of SARS-CoV-2 in the Development of COVID-19

J Zepeda-Cervantes, D Martínez-Flores… - Viruses, 2022 - mdpi.com
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is responsible for the
current pandemic affecting almost all countries in the world. SARS-CoV-2 is the agent …

Characterization of anti-SARS-CoV-2 monoclonal antibodies focusing on antigen binding, neutralization, and FcγR activation via formation of immune complex

M Tada, M Aoyama, A Ishii-Watabe - MAbs, 2023 - Taylor & Francis
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV− 2) causes coronavirus
disease 2019 (COVID− 19). Antibodies induced by SARS-CoV− 2 infection or vaccination …

In vitro: natural compounds (Thymol, Carvacrol, Hesperidine, and Thymoquinone) against Sars-Cov2 strain isolated from Egyptian patients

MG Seadawy, AF Gad, MF Elhoseny, BE ELharty… - bioRxiv, 2020 - biorxiv.org
The current pandemic of the coronavirus disease-2019 (COVID-19) has badly affected our
life during the year 2020. SARS-CoV-2 is the primary causative agent of the newly emerged …