Cancer immunotherapies such as tumor vaccines, chimeric antigen receptor T cells and
immune checkpoint blockades, have attracted tremendous attention. Among them, tumor …

Therapeutic tumor vaccines have attracted considerable attention in the past decade; they
can induce tumor regression, eradicate minimal residual disease, establish lasting immune …

Despite multiple immunotherapeutic technologies that achieve potent T cell activation,
effector T cells still lack efficiency because of the highly immunosuppressive conditions in …

Tumor vaccine is a promising cancer treatment modality, however, the convenient antigens
loading in vivo and efficient delivery of vaccines to lymph nodes (LNs) still remain a …

Immunotherapy has become a promising research “hotspot” in cancer treatment.“Soldier”
immune cells are not uniform throughout the body; they accumulate mostly in the immune …

Though increasing understanding and remarkable clinical successes have been made,
enormous challenges remain to be solved in the field of cancer immunotherapy. In this …

In recent years, personalized cancer vaccines have gained increasing attention as emerging
immunotherapies with the capability to overcome interindividual differences and show great …

T cells are often referred to as the 'guided missiles' of our immune system because of their
capacity to traffic to and accumulate at sites of infection or disease, destroy infected or …

Adjuvant, as an important part of vaccines, can observably enhance the magnitude, breadth
and durability of immune responses. Nanoadjuvants, as novel vaccine adjuvants, have …

Undesired dendritic cell (DC) spatiotemporal orchestration and innate immune stimulation
severely dampens anti-tumor efficacy of cancer vaccines. Here, we develop a manganese …