Mass spectrometry-intensive top-down proteomics: an update on technology advancements and biomedical applications

T Xu, Q Wang, Q Wang, L Sun - Analytical Methods, 2024 - pubs.rsc.org
Proteoforms are all forms of protein molecules from the same gene because of variations at
the DNA, RNA, and protein levels, eg, alternative splicing and post-translational …

Pilot Evaluation of the Long-Term Reproducibility of Capillary Zone Electrophoresis–Tandem Mass Spectrometry for Top-Down Proteomics of a Complex Proteome …

SA Sadeghi, W Chen, Q Wang, Q Wang… - Journal of Proteome …, 2024 - ACS Publications
Mass spectrometry (MS)-based top-down proteomics (TDP) has revolutionized biological
research by measuring intact proteoforms in cells, tissues, and biofluids. Capillary zone …

Mass spectrometry-based top-down proteomics in nanomedicine: proteoform-specific measurement of protein corona

SA Sadeghi, AA Ashkarran, M Mahmoudi, L Sun - bioRxiv, 2024 - biorxiv.org
Conventional mass spectrometry (MS)-based bottom-up proteomics (BUP) analysis of
protein corona [ie, an evolving layer of biomolecules, mostly proteins, formed on the surface …