Evidence suggests that the CXC–chemokine receptor-4 pathway plays a role in cancer cell
homing and metastasis, and thus represents a potential target for cancer therapy. The …

The cancer stem cell (CSC) hypothesis, despite the limitations of the currently available
models and assays, has ushered in a new era of excitement in cancer research. The …

Current treatments for clear cell renal cell cancer (ccRCC) are insufficient because two-
thirds of patients with metastases progress within two years. Here we report the identification …

Inactivation of the von Hippel-Lindau tumor suppressor gene, VHL, is an archetypical tumor-
initiating event in clear cell renal carcinoma (ccRCC) that leads to the activation of hypoxia …

Hypoxia has been identified as a common contributor to tumor progression, including
invasion and metastasis. However, the underlying mechanisms of enhanced invasion and …

In many solid tumors, cancer stem cells (CSC) represent a population with tumor-initiating,
self-renewal, and differentiation potential, which can be identified by surface protein …

Renal cell carcinoma (RCC) constitutes more than 90% of primary kidney tumors with the
development of metastatic disease in the lung, bone, liver, and brain. Clear-cell RCC …

Due to the lack of effective strategies on the treatment of castration resistant prostate cancer
(CRPC), we established a multifunctional nanoplatform (GNS@ IR820/DTX-CD133) for the …

Despite significant improvements in clinical management, pancreatic cancer (PC) remains
one of the deadliest cancer types, as it is prone to late detection with extreme metastatic …

The cancer stem cell (CSC) model has recently been approached also in renal cell
carcinoma (RCC). A few populations of putative renal tumor-initiating cells (TICs) were …