Highlights•Wnt signalling from the plasma membrane to the nucleus involves multiprotein
complexes.•Mechanistic principles underlying the assembly of these complexes are …

The Wnt signaling pathway is a highly conserved system that regulates complex biological
processes across all metazoan species. At the cellular level, secreted Wnt proteins serve to …

Frizzleds (FZDs) are G protein–coupled receptors (GPCRs) that bind to WNT family ligands.
FZDs signal through multiple effector proteins, including Dishevelled (DVL), which acts as a …

Isoprenoids are a very large and diverse family of metabolites required by all living
organisms. All isoprenoids derive from the double-bond isomers isopentenyl diphosphate …

For more than 30 years, WNT/β-catenin and planar cell polarity signaling has formed the
basis for what we understand to be the primary output of the interaction between WNTs and …

WNT signaling is fundamental in development and homeostasis, but how the Frizzled
receptors (FZDs) propagate signaling remains enigmatic. Here, we present the cryo-EM …

Idiopathic pulmonary fibrosis (IPF), a progressive and fatal lung disease, usually leads to an
irreversible distortion of the pulmonary structure. The functional roles of bone marrow …

The Wnt signaling is of paramount pathophysiological importance. Despite showing
promising anticancer activities in pre-clinical studies, current Wnt pathway inhibitors face …

Class F receptors are considered valuable therapeutic targets due to their role in human
disease, but structural changes accompanying receptor activation remain unexplored …

Wnt/β‐catenin signalling is initiated by a ternary Wnt‐Frizzled (FZD)‐LDL receptor‐related
protein (LRP) 5/6 binding event. The resulting conformational changes in the FZD and …