[HTML][HTML] Alternative splicing and related RNA binding proteins in human health and disease
Y Tao, Q Zhang, H Wang, X Yang, H Mu - Signal Transduction and …, 2024 - nature.com
Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …
engendering transcript diversity, and modifications in protein structure and functionality …
Overcoming cancer drug-resistance calls for novel strategies targeting abnormal alternative splicing
J Zhang, X Xu, H Deng, L Liu, Y Xiang… - Pharmacology & …, 2024 - Elsevier
Abnormal gene alternative splicing (AS) events are strongly associated with cancer
progression. Here, we summarize AS events that contribute to the development of drug …
progression. Here, we summarize AS events that contribute to the development of drug …
The splicing factor SNRPB promotes ovarian cancer progression through regulating aberrant exon skipping of POLA1 and BRCA2
Y Li, Z Chen, J Peng, C Yuan, S Yan, N Yang, P Li… - Oncogene, 2023 - nature.com
Splicing factors play a crucial role in the initiation and development of various human
cancers. SNRPB, a core spliceosome component, regulates pre-mRNA alternative splicing …
cancers. SNRPB, a core spliceosome component, regulates pre-mRNA alternative splicing …
[HTML][HTML] SRSF10 facilitates HCC growth and metastasis by suppressing CD8+ T cell infiltration and targeting SRSF10 enhances anti-PD-L1 therapy
X Luo, Z Zhang, S Li, Y Wang, M Sun, D Hu… - International …, 2024 - Elsevier
Background and Aims RNA splicing is an essential step in regulating the gene
posttranscriptional expression. Serine/arginine-rich splicing factors (SRSFs) are splicing …
posttranscriptional expression. Serine/arginine-rich splicing factors (SRSFs) are splicing …
[HTML][HTML] SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
J Li, H Jiang, Y Mu, Z Wei, A Ma, M Sun, J Zhao, C Zhu… - Iscience, 2023 - cell.com
Alternative pre-mRNA splicing plays critical roles in brain development. SRSF10 is a
splicing factor highly expressed in central nervous system and plays important roles in …
splicing factor highly expressed in central nervous system and plays important roles in …
Targeting serine-and arginine-rich splicing factors to rectify aberrant alternative splicing
D Li, W Yu, M Lai - Drug Discovery Today, 2023 - Elsevier
Serine-and arginine-rich splicing factors are pivotal modulators of constitutive splicing and
alternative splicing that bind to the cis-acting elements in precursor mRNAs and facilitate the …
alternative splicing that bind to the cis-acting elements in precursor mRNAs and facilitate the …
Assessing the Impact of Novel BRCA1 Exon 11 Variants on Pre-mRNA Splicing
Our study focused on assessing the effects of three newly identified BRCA1 exon 11 variants
(c. 1019T> C, c. 2363T> G, and c. 3192T> C) on breast cancer susceptibility. Using …
(c. 1019T> C, c. 2363T> G, and c. 3192T> C) on breast cancer susceptibility. Using …
[HTML][HTML] Exploring serine-arginine rich splicing factors: potential predictive markers for dysregulation in oral cancer
Background Dysregulated splicing events are a common phenomenon in cancer with the
Serine-arginine-rich splicing factor (SRSF) family emerging as pivotal regulators of gene …
Serine-arginine-rich splicing factor (SRSF) family emerging as pivotal regulators of gene …
SRSF10 regulates migration of neural progenitor cells and granule cells and affects the formation of dentate gyrus during the development of mouse hippocampus
A Ma, Y Mu, Z Wei, M Sun, J Li, H Jiang, C Zhu, X Chen - Neuroscience, 2024 - Elsevier
Hippocampus is a critical component of the central nervous system. SRSF10 is expressed in
central nervous system and plays important roles in maintaining normal brain functions …
central nervous system and plays important roles in maintaining normal brain functions …
[HTML][HTML] Machine learning for identifying tumor stemness genes and developing prognostic model in gastric cancer
GX Li, YP Chen, YY Hu, WJ Zhao, YY Lu… - Aging (Albany …, 2024 - ncbi.nlm.nih.gov
Gastric cancer presents a formidable challenge, marked by its debilitating nature and often
dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in …
dire prognosis. Emerging evidence underscores the pivotal role of tumor stem cells in …