Persistent pulmonary hypertension of the newborn (PPHN) is a syndrome of failed
circulatory adaptation at birth, seen in about 2/1000 live born infants. While it is mostly seen …

In contrast to early lung development, a process exemplified by the branching of the
developing airways, the later development of the immature lung remains very poorly …

Many studies have shown that TLR4-and TLR2-deficient mice are protected from high-fat
diet–induced inflammation and insulin resistance, suggesting that saturated fatty acids …

The pathogenesis of pulmonary hypertension is a complex multifactorial process that
involves the remodeling of pulmonary arteries. This remodeling process encompasses …

Oxidative stress can be associated with hyperoxia and hypoxia and is characterized by an
increase in reactive oxygen (ROS) and nitrogen (RNS) species generated by an underlying …

Pulmonary arterial hypertension (PAH) is a progressive disease of the lung vasculature that
involves the loss of endothelial function together with inappropriate smooth muscle cell …

BACKGROUND: Mitochondrial dysfunction, characterized by impaired lipid metabolism and
heightened reactive oxygen species generation, results in lipid peroxidation and ferroptosis …

Effective ventilation of the lungs is essential in mediating pulmonary vasodilation at birth to
allow effective gas exchange and an increase in systemic oxygenation. Unsuccessful …

Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with
few treatment options. The underlying mechanisms of PAH appear to involve substantial …

Purpose Although increased oxidative stress is a major component of diabetic hypertensive
cardiomyopathy, research into the effects of antioxidants on cardiac remodeling remains …