Risk factors of severe COVID-19: a review of host, viral and environmental factors

L Zsichla, V Müller - Viruses, 2023 - mdpi.com
The clinical course and outcome of COVID-19 are highly variable, ranging from
asymptomatic infections to severe disease and death. Understanding the risk factors of …

Evolution of enhanced innate immune suppression by SARS-CoV-2 Omicron subvariants

AK Reuschl, LG Thorne, MVX Whelan… - Nature …, 2024 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) human adaptation resulted
in distinct lineages with enhanced transmissibility called variants of concern (VOCs) …

Protective immunity of SARS-CoV-2 infection and vaccines against medically attended symptomatic omicron BA. 4, BA. 5, and XBB reinfections in Singapore: a …

CY Tan, CJ Chiew, D Pang, VJ Lee, B Ong… - The Lancet Infectious …, 2023 - thelancet.com
Background Despite a large proportion of the population having been vaccinated and
infected, Singapore had SARS-CoV-2 waves driven by the BA. 5 and XBB sublineages of …

The viral fitness and intrinsic pathogenicity of dominant SARS-CoV-2 Omicron sublineages BA. 1, BA. 2, and BA. 5

H Shuai, JFW Chan, B Hu, Y Chai, C Yoon, H Liu… - …, 2023 - thelancet.com
Summary Background Among the Omicron sublineages that have emerged, BA. 1, BA. 2,
BA. 5, and their related sublineages have resulted in the largest number of infections. While …

Short-term effectiveness of the XBB. 1.5 updated COVID-19 vaccine against hospitalisation in Denmark: a national cohort study

CH Hansen, IR Moustsen-Helms… - The Lancet Infectious …, 2024 - thelancet.com
The vaccines currently form part of the national immunisation programmes in many countries
including Denmark. Both vaccines incorporate a monovalent component designed to target …

Omicron subvariant BA. 5 efficiently infects lung cells

M Hoffmann, LYR Wong, P Arora, L Zhang… - Nature …, 2023 - nature.com
Abstract The SARS-CoV-2 Omicron subvariants BA. 1 and BA. 2 exhibit reduced lung cell
infection relative to previously circulating SARS-CoV-2 variants, which may account for their …

Association of SARS-CoV-2 BA. 4/BA. 5 Omicron lineages with immune escape and clinical outcome

JA Lewnard, V Hong, JS Kim, SF Shaw, B Lewin… - Nature …, 2023 - nature.com
Expansion of the SARS-CoV-2 BA. 4 and BA. 5 Omicron subvariants in populations with
prevalent immunity from prior infection and vaccination, and associated burden of severe …

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors

S Xia, L Wang, F Jiao, X Yu, W Xu… - Emerging Microbes & …, 2023 - Taylor & Francis
Continuous emergence of the Omicron variant, along with its subvariants, has caused an
increasing number of infections, reinfections, and vaccine-breakthrough infections, seriously …

Emergence and antibody evasion of BQ, BA. 2.75 and SARS-CoV-2 recombinant sub-lineages in the face of maturing antibody breadth at the population level

A Akerman, V Milogiannakis, T Jean, C Esneau… - …, 2023 - thelancet.com
Summary Background The Omicron era of the COVID-19 pandemic commenced at the
beginning of 2022 and whilst it started with primarily BA. 1, it was latter dominated by BA. 2 …

Stability of hybrid versus vaccine immunity against BA. 5 infection over 8 months

J Malato, RM Ribeiro, E Fernandes… - The Lancet Infectious …, 2023 - thelancet.com
(A) Incidence of documented SARS-CoV-2 infection overlaid with the period of dominance of
the BA. 1 and BA. 2 variants, Jan 1–Apr 14, 2022, divided into 15-day sub-intervals (shades …