Alzheimer's disease (AD) is a complex and progressive neurodegenerative disorder. The
available therapy is limited to the symptomatic treatment and its efficacy remains …

Background. Cholinesterases are a group of serine hydrolases that split the neurotransmitter
acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and …

Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …

Acetylcholinesterase is involved in the termination of impulse transmission by rapid
hydrolysis of the neurotransmitter acetylcholine in numerous cholinergic pathways in the …

With 27 million cases worldwide documented in 2006, Alzheimer's disease (AD) constitutes
an overwhelming health, social, economic, and political problem to nations. Unless a new …

Abstract The cholinesterase inhibitors (ChE-Is) attenuate the cholinergic deficit underlying
the cognitive and neuropsychiatric dysfunctions in patients with AD. Inhibition of brain …

Covering: January 1980 to August 2005This review describes 183 compounds obtained
from plants and fungi which have been shown to inhibit acetylcholinesterase. The …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
abnormal protein modification, inflammation and memory impairment. Aggregated amyloid …

Butyrylcholinesterase (BChE) is regarded as a promising drug target as its levels and activity
significantly increase in the late stages of Alzheimer's disease. To discover novel BChE …

Acetylcholine is widely distributed in the nervous system and has been implicated to play a
critical role in cerebral cortical development, cortical activity, controlling cerebral blood flow …