Alcoholic liver disease (ALD) is a leading cause of cirrhosis, liver cancer, and acute and
chronic liver failure and as such causes significant morbidity and mortality. While alcohol …

Alcoholic liver disease (ALD) is the most prevalent type of chronic liver disease worldwide.
ALD can progress from alcoholic fatty liver (AFL) to alcoholic steatohepatitis (ASH), which is …

For a long time, superoxide generation by an NADPH oxidase was considered as an oddity
only found in professional phagocytes. Over the last years, six homologs of the cytochrome …

HCC (hepatocellular carcinoma) is the second leading cause of cancer deaths worldwide,
with several etiologic causes, mostly inflammation-associated. Different inflammatory …

Alcohol is eliminated from the body by various metabolic mechanisms. The primary enzymes
involved are aldehyde dehydrogenase (ALDH), alcohol dehydrogenase (ADH), cytochrome …

Abstract Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking,
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …

Reactive oxygen species (ROS) are highly reactive molecules that are naturally generated
in small amounts during the body's metabolic reactions and can react with and damage …

Ethanol-induced oxidative stress seems to play a major role in mechanisms by which
ethanol causes liver injury. Many pathways have been suggested to contribute to the ability …

The involvement of free radical mechanisms in the pathogenesis of alcoholic liver disease
(ALD) is demonstrated by the detection of lipid peroxidation markers in the liver and the …

Acute and chronic ethanol treatment has been shown to increase the production of reactive
oxygen species, lower cellular antioxidant levels, and enhance oxidative stress in many …