Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Schizophrenia is a chronic and debilitating neuropsychiatric disorder affecting
approximately 1% of the world's population. This disease is associated with considerable …

Several studies have demonstrated that intrastriatal injections of fibrillar α-synuclein in
rodent brain induced a Parkinson's disease-like propagation of Lewy body pathology with …

Background Studies of mitochondrial morphology vary in techniques. Most use one
morphological parameter while others describe mitochondria qualitatively. Because …

Acyl-CoA: glycerol-3-phosphate acyltransferase (GPAT) and acyl-CoA: 1-acyl-glycerol-3-
phosphate acyltransferase (AGPAT) are involved in the de novo synthesis of triacylglycerol …

The fruit fly Drosophila melanogaster has been a popular model to study cAMP signaling
and resultant behaviors due to its powerful genetic approaches. All molecular components …

Pathophysiological damages and loss of function of dopamine neurons precede their
demise and contribute to the early phases of Parkinson's disease. The presence of aberrant …

Neurotransmitters are crucial for the relay of signals between neurons and their target.
Monoamine neurotransmitters dopamine (DA), serotonin (5-HT), and histamine are found in …

The molecular mechanism responsible for degenerative process in the nigrostriatal
dopaminergic system in Parkinson's disease (PD) remains unknown. One major advance in …

Parkinson's disease (PD) relates to defective mitochondrial quality control in the
dopaminergic motor network. Genetic studies have revealed that PINK1 and Parkin …