Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

[HTML][HTML] Recent progress in treatment of hepatocellular carcinoma

Z Chen, H Xie, M Hu, T Huang, Y Hu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death
worldwide. In the past decade, there have been improvements in non-drug therapies and …

Apoptosis and necroptosis in the liver: a matter of life and death

RF Schwabe, T Luedde - Nature reviews Gastroenterology & …, 2018 - nature.com
Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …

Recent advances in oligonucleotide therapeutics in oncology

H Xiong, RN Veedu, SD Diermeier - International Journal of Molecular …, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …

Cell death and cell death responses in liver disease: mechanisms and clinical relevance

T Luedde, N Kaplowitz, RF Schwabe - Gastroenterology, 2014 - Elsevier
Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …

Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance

N Shahar, S Larisch - Drug Resistance Updates, 2020 - Elsevier
The cytotoxic effect of anti-cancer drugs relies on their ability to induce programmed cell
death known as apoptosis. Evading apoptosis is a common characteristic of cancer cells …

Inhibitors of apoptosis: clinical implications in cancer

MS Mohamed, MK Bishr, FM Almutairi, AG Ali - Apoptosis, 2017 - Springer
Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …

Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy

J Zhao, Y Hu, J Peng - Cellular & Molecular Biology Letters, 2021 - Springer
Most currently recommended therapies for metabolic dysfunction-associated fatty liver
disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and …

[HTML][HTML] Targeting the BIR domains of inhibitor of apoptosis (IAP) proteins in cancer treatment

F Cossu, M Milani, E Mastrangelo, D Lecis - Computational and Structural …, 2019 - Elsevier
Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved
baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs …

Is the era of sorafenib over? A review of the literature

G Fan, X Wei, X Xu - Therapeutic advances in medical …, 2020 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is one of the most severe diseases worldwide. For the
different stages of HCC, there are different clinical treatment strategies, such as surgical …