Clinical translation of nanomedicines: Challenges, opportunities, and keys
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …
limited number of formulations have found their way to the clinics. This shortcoming reveals …
[HTML][HTML] Recent progress in treatment of hepatocellular carcinoma
Z Chen, H Xie, M Hu, T Huang, Y Hu… - American journal of …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related death
worldwide. In the past decade, there have been improvements in non-drug therapies and …
worldwide. In the past decade, there have been improvements in non-drug therapies and …
Apoptosis and necroptosis in the liver: a matter of life and death
RF Schwabe, T Luedde - Nature reviews Gastroenterology & …, 2018 - nature.com
Cell death represents a basic biological paradigm that governs outcomes and long-term
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …
sequelae in almost every hepatic disease condition. Acute liver failure is characterized by …
Recent advances in oligonucleotide therapeutics in oncology
H Xiong, RN Veedu, SD Diermeier - International Journal of Molecular …, 2021 - mdpi.com
Cancer is one of the leading causes of death worldwide. Conventional therapies, including
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …
surgery, radiation, and chemotherapy have achieved increased survival rates for many types …
Cell death and cell death responses in liver disease: mechanisms and clinical relevance
Hepatocellular death is present in almost all types of human liver disease and is used as a
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …
sensitive parameter for the detection of acute and chronic liver disease of viral, toxic …
Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance
N Shahar, S Larisch - Drug Resistance Updates, 2020 - Elsevier
The cytotoxic effect of anti-cancer drugs relies on their ability to induce programmed cell
death known as apoptosis. Evading apoptosis is a common characteristic of cancer cells …
death known as apoptosis. Evading apoptosis is a common characteristic of cancer cells …
Inhibitors of apoptosis: clinical implications in cancer
Inhibitor of apoptosis (IAP) family comprises a group of endogenous proteins that function as
main regulators of caspase activity and cell death. They are considered the main culprits in …
main regulators of caspase activity and cell death. They are considered the main culprits in …
Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy
J Zhao, Y Hu, J Peng - Cellular & Molecular Biology Letters, 2021 - Springer
Most currently recommended therapies for metabolic dysfunction-associated fatty liver
disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and …
disease (MAFLD) involve diet control and exercise therapy. We searched PubMed and …
[HTML][HTML] Targeting the BIR domains of inhibitor of apoptosis (IAP) proteins in cancer treatment
Inhibitor of apoptosis (IAP) proteins are characterized by the presence of the conserved
baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs …
baculoviral IAP repeat (BIR) domain that is involved in protein-protein interactions. IAPs …
Is the era of sorafenib over? A review of the literature
G Fan, X Wei, X Xu - Therapeutic advances in medical …, 2020 - journals.sagepub.com
Hepatocellular carcinoma (HCC) is one of the most severe diseases worldwide. For the
different stages of HCC, there are different clinical treatment strategies, such as surgical …
different stages of HCC, there are different clinical treatment strategies, such as surgical …