Insulin and glucagon exert opposing effects on glucose metabolism and, consequently,
pancreatic islet β-cells and α-cells are considered functional antagonists. The intra-islet …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

The peptide hormone glucagon, discovered in late 1922, is secreted from pancreatic alpha
cells and is an essential regulator of metabolic homeostasis. This review summarises …

Hundred years after the discovery of glucagon, its biology remains enigmatic. Accurate
measurement of glucagon has been essential for uncovering its pathological hypersecretion …

Glucagon is secreted from islet α cells and controls blood levels of glucose in the fasting
state. Impaired glucagon secretion predisposes some patients with type 1 diabetes mellitus …

Hyperinsulinemia is an adaptive mechanism that enables the maintenance of
normoglycemia in the presence of insulin resistance. We assessed whether glucagon is also …

Importance Compared with the general population, patients with schizophrenia have a 2-to
3-fold higher mortality rate primarily caused by cardiovascular disease. Previous …

Glucagon is believed to be a pancreas-specific hormone, and hyperglucagonemia has been
shown to contribute significantly to the hyperglycemic state of patients with diabetes. This …

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones
insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and …

Glucagon is historically described as the counterregulatory hormone to insulin, induced by
fasting/hypoglycemia to raise blood glucose through action mediated in the liver. However, it …