The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of
cancer types. Unfortunately, many cancers initially respond to platinum treatment but when …

Cisplatin-based chemotherapy is the standard of care for patients with muscle-invasive
urothelial carcinoma. Pathologic downstaging to pT0/pTis after neoadjuvant cisplatin-based …

Background Chemotherapy is a standard therapeutic regimen to treat triple-negative breast
cancer (TNBC); however, chemotherapy alone does not result in significant improvement …

Cellular DNA is susceptible to chemical modifications when exposed to various
environmental agents, chemotherapeutic agents, or endogenous agents produced by …

Lung cancer is the most common cancer, with dismal outcome. Treatment approaches,
including cisplatin-based chemotherapy and surgery, are currently based on the clinical …

Platinum based therapy is one of the most effectively used chemotherapeutic treatments for
cancer. The mechanism of action of platinum compounds is to damage DNA and drive cells …

Background: Impaired DNA repair capacity may favorably affect survival in
cisplatin/gemcitabine-treated non-small-cell lung cancer (NSCLC) patients. We investigated …

Despite advances in our understanding of the molecular biology of the disease and
improved therapeutics, lung cancer remains the most common cause of cancer-related …

Background Recent evidence has proven that long noncoding RNAs (lncRNAs) play
important roles in cancer biology, while few lncRNAs have been characterized in NSCLC …