Major depressive disorder (MDD) was previously hypothesized to be a disease of
monoamine deficiency in which low levels of monoamines in the synaptic cleft were …

Chronic stress and depressive-like behaviors in basic neuroscience research have been
associated with impairments of neuroplasticity, such as neuronal atrophy and synaptic loss …

The array of end organ innervations of the vagus nerve, coupled with increased basic
science evidence, has led to vagus nerve stimulation (VNS) being explored as a …

Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are
important to develop more targeted and effective strategies to prevent suicide. In the last …

Major depressive disorder (MDD) affects multiple large-scale functional networks in the
brain, which has initiated a large number of studies on resting-state functional connectivity in …

Fluctuations in reproductive hormone levels are associated with mood disruptions in
women, such as in postpartum and perimenopausal depression. However, the neural circuit …

Understanding the neural substrates of depression is crucial for diagnosis and treatment.
Here, we review recent studies of functional and effective connectivity in depression, in …

Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for developing chronic pain. Within this context, we revisit the concepts for nociception, acute …

There is no definitive neural marker of suicidal thoughts and behaviors (STBs) or
nonsuicidal self-injury (NSSI), and relative to adults, research in youth is more limited. This …

Youth depression has been associated with heterogenous patterns of aberrant brain
connectivity. To make sense of these divergent findings, we conducted a systematic review …