[HTML][HTML] Circular RNAs: new layer of complexity evading breast cancer heterogeneity

A Dawoud, ZI Zakaria, HH Rashwan… - Non-Coding RNA …, 2023 - Elsevier
Advances in high-throughput sequencing techniques and bioinformatic analysis have
refuted the “junk” RNA hypothesis that was claimed against non-coding RNAs (ncRNAs) …

Circular RNAs as potential biomarkers in breast cancer

FDE De Palma, F Salvatore, JG Pol, G Kroemer… - Biomedicines, 2022 - mdpi.com
Due to the high heterogeneity and initially asymptomatic nature of breast cancer (BC), the
management of this disease depends on imaging together with immunohistochemical and …

Current therapeutic approaches and promising perspectives of using bioengineered peptides in fighting chemoresistance in triple-negative breast cancer

M Azari, F Bahreini, VN Uversky, N Rezaei - Biochemical Pharmacology, 2023 - Elsevier
Breast cancer is a collation of malignancies that manifest in the mammary glands at the early
stages. Among breast cancer subtypes, triple-negative breast cancer (TNBC) shows the …

Circular RNAs: biology and clinical significance of breast cancer

Z Wang, H Deng, Y Jin, M Luo, J Huang, J Wang… - RNA biology, 2023 - Taylor & Francis
Circular RNAs (circRNAs) are novel noncoding RNAs with covalently closed-loop structures
that can regulate eukaryotic gene expression. Due to their stable structure, circRNAs are …

Investigation of BRCAness associated miRNA-gene axes in breast cancer: cell-free miR-182-5p as a potential expression signature of BRCAness

F Darbeheshti, S Kadkhoda, M Keshavarz-Fathi, S Razi… - BMC cancer, 2022 - Springer
The concept of the 'BRCAness' phenotype implies the properties that some sporadic breast
cancers (BC) share with BRCA1/2-mutation carriers with hereditary BC. Breast tumors with …

Unraveling Biomarker Signatures in Triple-Negative Breast Cancer: A Systematic Review for Targeted Approaches

P Pastena, H Perera, A Martinino, W Kartsonis… - International Journal of …, 2024 - mdpi.com
Triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer, marked by poor outcomes and dismal prognosis. Due to the absence of targetable …

[HTML][HTML] Circular RNAs in and out of cells: therapeutic usages of circular RNAs

M Ju, D Kim, G Son, J Han - Molecules and cells, 2023 - Elsevier
RNAs are versatile molecules that are primarily involved in gene regulation and can thus be
widely used to advance the fields of therapeutics and diagnostics. In particular, circular …

Prospect of exosomal circular RNAs in breast Cancer: presents and future

E Zokaei, F Darbeheshti, N Rezaei - Molecular Biology Reports, 2022 - Springer
Implementing precision oncology for breast cancer (BC) is a critical method for improving
patient outcomes, which relies on the use of reliable biomarkers to be effective and safe …

Evaluation of circ_0000977-mediated regulatory network in breast cancer: A potential discriminative biomarker for triple-negative tumors

F Darbeheshti, Y Mansoori, G Azizi-Tabesh… - Biochemical …, 2023 - Springer
Previous investigations have revealed that circular RNAs (circRNAs) play pivotal roles in
cancer development and progression by participating in several biological procedures, such …

Exploiting Long Non-Coding RNAs and Circular RNAs as Pharmacological Targets in Triple-Negative Breast Cancer Treatment

AC Palcau, R Brandi, NH Mehterov, C Botti, G Blandino… - Cancers, 2023 - mdpi.com
Simple Summary Triple-negative breast cancer accounts for 15–20% of breast tumors. It is a
very aggressive and heterogeneous disease characterized by the absence of druggable …