Background Major depressive disorder (MDD) is a global public health concern. In
particular, treatment-resistant depression (TRD) represents a key unmet need in the …

The Sequenced Treatment Alternatives to Relieve Depression (STAR* D) study evaluated
feasible treatment strategies to improve clinical outcomes for real-world patients with …

Abstract Study Objective: To compare cognitive behavioral therapy for insomnia (CBT-I)+
antidepressant medication (AD) against treatments that target solely depression or solely …

Background Post-traumatic stress disorder (PTSD) is a severe and disabling condition that
may lead to functional impairment and reduced productivity. Psychological interventions …

Abstract The STAR* D (Sequenced Treatment Alternatives to Relieve Depression) study
used a series of sequenced, randomized treatment trials following a first and, if needed …

BACKGROUND: Antidepressants are the first-line treatment for depression, yet medication-
related side effects may be associated with antidepressant discontinuation before reaching …

Summary Abstract Escitalopram (Cipralex®, Lexapro™), the active S-enantiomer of the
racemic selective serotonin reuptake inhibitor (SSRI) citalopram (RS-citalopram), is a highly …

Background: When guidelines for health economic evaluations prescribe that a societal
perspective should be adopted, productivity costs should be included. However, previous …

Background Whether the acute outcomes of major depressive disorder (MDD) treated in
primary (PC) or specialty care (SC) settings are different is unknown. Objective To compare …

Background Repetitive transcranial magnetic stimulation (rTMS) therapy is a clinically safe,
noninvasive, nonsystemic treatment for major depressive disorder. Objective We evaluated …