Triple negative breast cancer (TNBC) is a complex and aggressive subtype of breast cancer
which lacks oestrogen receptors, progesterone receptors and HER2 amplification, thereby …

Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable
cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of …

Membrane potential (Vm), the voltage across the plasma membrane, arises because of the
presence of different ion channels/transporters with specific ion selectivity and permeability …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Plasma membrane (PM) ion channels contribute to virtually all basic cellular processes and
are also involved in the malignant phenotype of cancer cells. Here, we review the role of ion …

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …

Changes of the electrical charges across the surface cell membrane are absolutely
necessary to maintain cellular homeostasis in physiological as well as in pathological …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience.
Sodium channels Nav1. 1–Nav1. 3 and Nav1. 6–Nav1. 9 support electrogenesis in neurons …

Cancer is a disease with marked heterogeneity in both response to therapy and survival.
Clinical and histopathological characteristics have long determined prognosis and therapy …