In addition to being a vital organ for gas exchange, the lung is a crucial immune organ
continuously exposed to the external environment. Genetic defects that impair immune …

B cells are a class of professional antigen-presenting cells that produce antibodies to
mediate humoral immune response and participate in immune regulation. m6A modification …

Importance Lifelong immunoglobulin replacement therapy (IRT) is standard-of-care
treatment for congenital agammaglobulinemia but accrues high annual costs ($30 000-$90 …

Background Bruton's tyrosine kinase (BTK) is a cytoplasmic protein involved in the B cell
development. X-linked agammaglobulinemia (XLA) is caused by mutation in the BTK gene …

Primary immunodeficiency disorders (PIDs), which are humoral, combined, and innate
defects of the immune system, are relatively uncommon and may go undiagnosed in …

Although the majority of monogenic defects underlying primary immunodeficiency are
microlesions, large lesions like large deletions are rare and constitute less than 10% of …

Background: Selective IgA deficiency (SIgAD), is known as the most common antibody
deficiency. This study, investigated the respiratory disorders among these patients. Method …

likely to develop bronchiectasis than individuals with other PIDs owing to their functioning
IgG antibodies (4). In a cohort of 330 patients with selective IgA deficiency, Domínguez et al …