An update of safety of clinically used atypical antipsychotics

L Orsolini, C Tomasetti, A Valchera… - Expert opinion on …, 2016 - Taylor & Francis
ABSTRACT Introduction: The atypical antipsychotic (APs) drugs have become the most
widely used agents to treat a variety of psychoses because of their superiority with regard to …

The gut microbiome in schizophrenia and the potential benefits of prebiotic and probiotic treatment

JCW Liu, I Gorbovskaya, MK Hahn, DJ Müller - Nutrients, 2021 - mdpi.com
The gut microbiome (GMB) plays an important role in developmental processes and has
been implicated in the etiology of psychiatric disorders. However, the relationship between …

Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota

ACC Kao, S Spitzer, DC Anthony, B Lennox… - Translational …, 2018 - nature.com
Olanzapine is an effective antipsychotic drug but since it causes significant weight gain, it is
not well tolerated by psychosis patients. The prebiotic, B-GOS®, attenuates metabolic …

Molecular mechanisms of antipsychotic drug-induced diabetes

J Chen, XF Huang, R Shao, C Chen… - Frontiers in …, 2017 - frontiersin.org
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As
mental disorders are chronic diseases, these drugs are often used over a life-time. However …

[HTML][HTML] Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight

V Ferreira, C Folgueira, M Guillén, P Zubiaur… - Metabolism, 2022 - Elsevier
Abstract Background Second-generation antipsychotics (SGAs) are a mainstay therapy for
schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and …

Antipsychotics promote metabolic disorders disrupting cellular lipid metabolism and trafficking

C Vantaggiato, E Panzeri, A Citterio, G Orso… - Trends in Endocrinology …, 2019 - cell.com
Antipsychotics frequently cause obesity and related metabolic disorders that current
psychopharmacological/endocrinological theories do not explain consistently. An …

[HTML][HTML] Preclinical and clinical sex differences in antipsychotic-induced metabolic disturbances: a narrative review of adiposity and glucose metabolism

LN Castellani, KA Costa-Dookhan… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
Antipsychotic (AP) medications are associated with an increased risk of developing
metabolic side effects including weight gain, type 2 diabetes (T2D), dyslipidemia, and …

[HTML][HTML] Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via …

V Ferreira, C Folgueira, M García-Altares, M Guillén… - Redox Biology, 2023 - Elsevier
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight
gain and metabolic alterations when administered orally to patients. Recently, we …

Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model

K Horska, S Skrede, J Kucera… - CNS Neuroscience …, 2024 - Wiley Online Library
Aim Widely used second‐generation antipsychotics are associated with adverse metabolic
effects, contributing to increased cardiovascular mortality. To develop strategies to prevent …

[HTML][HTML] Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view

V Ferreira, D Grajales, ÁM Valverde - … (BBA)-Molecular and Cell Biology of …, 2020 - Elsevier
Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people
worldwide. Second-generation antipsychotics (SGAs) are the cornerstone in the …