An update of safety of clinically used atypical antipsychotics
L Orsolini, C Tomasetti, A Valchera… - Expert opinion on …, 2016 - Taylor & Francis
ABSTRACT Introduction: The atypical antipsychotic (APs) drugs have become the most
widely used agents to treat a variety of psychoses because of their superiority with regard to …
widely used agents to treat a variety of psychoses because of their superiority with regard to …
The gut microbiome in schizophrenia and the potential benefits of prebiotic and probiotic treatment
The gut microbiome (GMB) plays an important role in developmental processes and has
been implicated in the etiology of psychiatric disorders. However, the relationship between …
been implicated in the etiology of psychiatric disorders. However, the relationship between …
Prebiotic attenuation of olanzapine-induced weight gain in rats: analysis of central and peripheral biomarkers and gut microbiota
ACC Kao, S Spitzer, DC Anthony, B Lennox… - Translational …, 2018 - nature.com
Olanzapine is an effective antipsychotic drug but since it causes significant weight gain, it is
not well tolerated by psychosis patients. The prebiotic, B-GOS®, attenuates metabolic …
not well tolerated by psychosis patients. The prebiotic, B-GOS®, attenuates metabolic …
Molecular mechanisms of antipsychotic drug-induced diabetes
Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As
mental disorders are chronic diseases, these drugs are often used over a life-time. However …
mental disorders are chronic diseases, these drugs are often used over a life-time. However …
[HTML][HTML] Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight
V Ferreira, C Folgueira, M Guillén, P Zubiaur… - Metabolism, 2022 - Elsevier
Abstract Background Second-generation antipsychotics (SGAs) are a mainstay therapy for
schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and …
schizophrenia. SGA-treated patients present higher risk for weight gain, dyslipidemia and …
Antipsychotics promote metabolic disorders disrupting cellular lipid metabolism and trafficking
C Vantaggiato, E Panzeri, A Citterio, G Orso… - Trends in Endocrinology …, 2019 - cell.com
Antipsychotics frequently cause obesity and related metabolic disorders that current
psychopharmacological/endocrinological theories do not explain consistently. An …
psychopharmacological/endocrinological theories do not explain consistently. An …
[HTML][HTML] Preclinical and clinical sex differences in antipsychotic-induced metabolic disturbances: a narrative review of adiposity and glucose metabolism
LN Castellani, KA Costa-Dookhan… - Journal of psychiatry …, 2019 - ncbi.nlm.nih.gov
Antipsychotic (AP) medications are associated with an increased risk of developing
metabolic side effects including weight gain, type 2 diabetes (T2D), dyslipidemia, and …
metabolic side effects including weight gain, type 2 diabetes (T2D), dyslipidemia, and …
[HTML][HTML] Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via …
V Ferreira, C Folgueira, M García-Altares, M Guillén… - Redox Biology, 2023 - Elsevier
Olanzapine (OLA), a widely used second-generation antipsychotic (SGA), causes weight
gain and metabolic alterations when administered orally to patients. Recently, we …
gain and metabolic alterations when administered orally to patients. Recently, we …
Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model
K Horska, S Skrede, J Kucera… - CNS Neuroscience …, 2024 - Wiley Online Library
Aim Widely used second‐generation antipsychotics are associated with adverse metabolic
effects, contributing to increased cardiovascular mortality. To develop strategies to prevent …
effects, contributing to increased cardiovascular mortality. To develop strategies to prevent …
[HTML][HTML] Adipose tissue as a target for second-generation (atypical) antipsychotics: A molecular view
V Ferreira, D Grajales, ÁM Valverde - … (BBA)-Molecular and Cell Biology of …, 2020 - Elsevier
Schizophrenia is a neuropsychiatric disorder that chronically affects 21 million people
worldwide. Second-generation antipsychotics (SGAs) are the cornerstone in the …
worldwide. Second-generation antipsychotics (SGAs) are the cornerstone in the …