Transient physical association between enzymes appears to be a cardinal feature of
metabolic systems, yet the purpose of this metabolic organisation remains enigmatic. It is …

Lipoic acid is an essential cofactor for mitochondrial metabolism and is synthesized de novo
using intermediates from mitochondrial fatty-acid synthesis type II, S-adenosylmethionine …

Recent experimental evidence has replaced the random diffusion model of electron transfer
with a model of supramolecular organisation based upon specific interactions between …

Metabolic activities in cells are compartmented into various structures and organelles. In
each compartment [outer cell membrane, Golgi, endoplasmic reticulum (rough and smooth) …

Mitochondria-produced reactive oxygen species (ROS) are thought to contribute to cell
death caused by a multitude of pathological conditions. The molecular sites of mitochondrial …

Mitochondrial β‐oxidation is a complex pathway involving, in the case of saturated straight
chain fatty acids of even carbon number, at least 16 proteins which are organized into two …

The inner membranes of mitochondria contain three multi-subunit enzyme complexes that
act successively to transfer electrons from NADH to oxygen, which is reduced to water (Fig …

The control of mitochondrial β-oxidation, including the delivery of acyl moieties from the
plasma membrane to the mitochondrion, is reviewed. Control of β-oxidation flux appears to …

Almost a century has passed since Knoop performed his classical feeding experiments that
led him to propose the principle of fl-oxidation for the degradation of fatty acids. After …

The enzymatic complexes of the mitochondrial respiratory chain have been extensively
investigated in their structural and functional properties. A clear distinction is possible today …