[HTML][HTML] BP-M345 as a Basis for the Discovery of New Diarylpentanoids with Promising Antimitotic Activity

J Moreira, PMA Silva, E Castro, L Saraiva… - International Journal of …, 2024 - mdpi.com
Recently, the diarylpentanoid BP-M345 (5) has been identified as a potent in vitro growth
inhibitor of cancer cells, with a GI50 value between 0.17 and 0.45 µM, showing low toxicity in …

Utility of 2-Chloro-N-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]

ME Salem, AH Abdullah, MEA Zaki, IA Abdelhamid… - ACS …, 2024 - ACS Publications
A series of novel thieno [2, 3-b] pyridines linked to N-aryl carboxamides or
(carbonylphenoxy)-N-(aryl) acetamides, as well as bis (thieno [2, 3-b] pyridines) linked to …

Synthesis of Novel Diphenyl Ether-Based Bis-Heterocycles as Novel Hybrid Molecules via Michael and Other Cyclocondensation Reactions

ME Salem, YA El-Gabry, IA Abdelhamid… - ACS …, 2024 - ACS Publications
Molecular hybridization is a technique used in drug creation that involves combining the
pharmacophoric moieties of multiple bioactive compounds to create a new hybrid molecule …

Thiazolidinone-linked-1, 2, 3-triazoles with (R)-Carvone as new potential anticancer agents

A Oubella, MA Alossaimi, Y Riadi, MA Bhat… - Future Medicinal …, 2024 - Taylor & Francis
Aim: This study explores the cytotoxic and apoptotic effects of novel thiazolidinone-1, 2, 3-
triazole hybrids on HT-1080, A-549, and MDA-MB-231 cancer cell lines. Methods & results …