Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …

Subcellular compartmentalization contributes to the organization of a plethora of molecular
events occurring within cells. This can be achieved in membraneless organelles generated …

Chromosomal rearrangements including large DNA-fragment inversions, deletions, and
duplications by Cas9 with paired sgRNAs are important to investigate genome structural …

The three-dimensional structure of chromosomes plays an important role in gene expression
regulation and also influences the repair of radiation-induced DNA damage. Genomic …

Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Ageing is a crucial risk factor for Alzheimer's disease (AD) and is characterised by systemic
changes in both intracellular and extracellular microenvironments that affect the entire body …

Persistent infection with certain types of human papillomaviruses (HPVs), termed high risk,
presents a public health burden due to their association with multiple human cancers …

Meiotic recombination in vertebrates is concentrated in hotspots throughout the genome.
The location and stability of hotspots have been linked to the presence or absence of …

Monoallelic variants of CTCF cause an autosomal dominant neurodevelopmental disorder
with a wide range of features, including impacts on the brain, growth, and craniofacial …

Abstract Zinc-Finger (ZnF) proteins represent one of the most abundant group of proteins in
the human genome. At first characterized as DNA binding proteins, it has become …