Fetal alcohol spectrum disorders: Genetic and epigenetic mechanisms

N Kaminen‐Ahola - Prenatal diagnosis, 2020 - Wiley Online Library
Fetal alcohol spectrum disorders (FASD) are a consequence of prenatal alcohol exposure
(PAE). The etiology of the complex FASD phenotype with growth deficit, birth defects, and …

Transgenerational abnormalities induced by paternal preconceptual alcohol drinking: findings from humans and animal models

S Terracina, G Ferraguti, L Tarani… - Current …, 2022 - benthamdirect.com
Alcohol consumption during pregnancy and lactation is a widespread preventable cause of
neurodevelopmental impairment in newborns. While the harmful effects of gestational …

Epigenetics of the developing and aging brain: Mechanisms that regulate onset and outcomes of brain reorganization

ER Bacon, RD Brinton - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
Brain development is a life-long process that encompasses several critical periods of
transition, during which significant cognitive changes occur. Embryonic development …

Paternal alcohol exposures program intergenerational hormetic effects on offspring fetoplacental growth

KN Thomas, KN Zimmel, A Basel, AN Roach… - Frontiers in Cell and …, 2022 - frontiersin.org
Hormesis refers to graded adaptive responses to harmful environmental stimuli where low-
level toxicant exposures stimulate tissue growth and responsiveness while, in contrast …

Preconceptional paternal alcohol consumption and the risk of child behavioral problems: a prospective cohort study

M Luan, X Zhang, G Fang, H Liang, F Yang, X Song… - Scientific reports, 2022 - nature.com
Animal studies demonstrated that paternal alcohol exposure before conception increases
the risk of adverse neurodevelopment in offspring, but limited evidence is known in humans …

Transgenerational effects of prenatal ethanol exposure in prepubescent mice

RT Bottom, OO Kozanian, DJ Rohac… - Frontiers in Cell and …, 2022 - frontiersin.org
Background: Fetal alcohol spectrum disorders (FASD) represent a leading cause of non-
genetic neuropathologies. Recent preclinical evidence from suggests that prenatal ethanol …

[HTML][HTML] Nutrition and cognition across the lifetime: an overview on epigenetic mechanisms

A Polverino, P Sorrentino, M Pesoli… - AIMS …, 2021 - ncbi.nlm.nih.gov
The functioning of our brain depends on both genes and their interactions with
environmental factors. The close link between genetics and environmental factors produces …

Disruptive peers in the classroom and students' academic outcomes: Evidence and mechanisms

L Zhao, Z Zhao - Labour Economics, 2021 - Elsevier
In this study, we estimate the negative spillovers of children from troubled families linked to
alcoholic fathers, on the academic performance of other students in China. Specifically, we …

Paternal alcohol exposure has task‐and sex‐dependent behavioral effect in offspring

SJ Nieto, MJ Harding, DA Nielsen… - Alcoholism: Clinical …, 2022 - Wiley Online Library
Background Endophenotypes for alcohol use disorder are well known and may reflect
paternal exposure effects passed down to offspring via epigenetic mechanisms. Previously …

Diet and transgenerational epigenetic inheritance of breast cancer: the role of the paternal germline

RS Da Cruz, E Chen, M Smith, J Bates… - Frontiers in Nutrition, 2020 - frontiersin.org
The past decade has made evident that in addition to passing their genetic material at
conception, parents also transmit a molecular memory of past environmental experiences …