Oligonucleotides can be used to modulate gene expression via a range of processes
including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation …

Antisense technology is beginning to deliver on the broad promise of the technology. Ten
RNA-targeted drugs including eight single-strand antisense drugs (ASOs) and two double …

Antisense oligonucleotides (ASOs) interact with target RNAs via hybridization to modulate
gene expression through different mechanisms. ASO therapeutics are chemically modified …

Antisense oligonucleotides (ASOs) modified with phosphorothioate (PS) linkages and
different 2′ modifications can be used either as drugs (eg, to treat homozygous familial …

Long noncoding RNA (lncRNA) molecules are some of the newest and least understood
players in gene regulation. Hence, we need good model systems with well-defined RNA and …

The molecular mechanisms of toxicity of chemically modified phosphorothioate antisense
oligonucleotides (PS-ASOs) are not fully understood. Here, we report that toxic gapmer PS …

In 1987, when I became interested in the notion of antisense technology, I returned to my
roots in RNA biochemistry and began work to understand how oligonucleotides behave in …

Aberrant overexpression of the long non‐coding RNA NEAT 1 (nuclear paraspeckle
assembly transcript 1) has been documented in different types of solid tumours, such as lung …

RNase H1-dependent antisense oligonucleotides (ASOs) are active in reducing levels of
both cytoplasmic mRNAs and nuclear retained RNAs. Although ASO activity in the nucleus …

Biomolecular condensates organize cellular functions in the absence of membranes. These
membraneless organelles can form through liquid–liquid phase separation coalescing RNA …