The Collaborative Cross (CC) and the complementary Diversity Outbred (DO) population
were conceived as a platform for the next generation of studies of the genetic basis for …

In 1989 ILAR published a list and description of immunodeficient rodents used in research.
Since then, advances in understanding of molecular mechanisms; recognition of genetic …

Myocarditis has emerged as an immune-related adverse event of immune checkpoint
inhibitor (ICI) cancer therapy associated with significant mortality. To ensure patients …

Most natural history models for type 1 diabetes (T1D) propose that overt hyperglycemia
results after a progressive loss of insulin-secreting β-cell mass and/or function. To …

Tobacco smoking is the major cause of disability and death in the United States and around
the world. In addition, tobacco dependence and addiction express themselves as complex …

Viral vectors are complex drugs that pose a particular challenge for manufacturing. Previous
studies have shown that, unlike small-molecule drugs, vector preparations do not yield a …

In an effort to improve HLA-“humanized” mouse models for type 1 diabetes (T1D) therapy
development, we previously generated directly in the NOD strain CRISPR/Cas9-mediated …

The role of interferons, either pathogenic or protective, during autoimmune diabetes remains
controversial. Herein, we examine the progression of diabetes in NOD mice lacking the type …

Abstract Type 1 diabetes (T1D) in both humans and NOD mice is caused by T cell–mediated
autoimmune destruction of pancreatic β cells. Increased frequency or activity of autoreactive …

Patients with type 1 diabetes mellitus (T1DM) exhibit reduced BMD and significant increases
in fracture risk. Changes in BMD are attributed to blunted osteoblast activity and inhibited …