Genetics of chronic respiratory disease
Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD),
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
asthma and interstitial lung diseases are frequently occurring disorders with a polygenic …
Lung-function trajectories: relevance and implementation in clinical practice
Lung development starts in utero and continues during childhood through to adolescence,
reaching its peak in early adulthood. This growth is followed by gradual decline due to …
reaching its peak in early adulthood. This growth is followed by gradual decline due to …
Unsupervised representation learning on high-dimensional clinical data improves genomic discovery and prediction
Although high-dimensional clinical data (HDCD) are increasingly available in biobank-scale
datasets, their use for genetic discovery remains challenging. Here we introduce an …
datasets, their use for genetic discovery remains challenging. Here we introduce an …
Genotyping and population characteristics of the China Kadoorie Biobank
RG Walters, IY Millwood, K Lin, DS Valle, P McDonnell… - Cell Genomics, 2023 - cell.com
Summary The China Kadoorie Biobank (CKB) is a population-based prospective cohort of>
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
512,000 adults recruited from 2004 to 2008 from 10 geographically diverse regions across …
Pathophysiology and genomics of bronchiectasis
Bronchiectasis is a complex and heterogeneous inflammatory chronic respiratory disease
with an unknown cause in around 30–40% of patients. The presence of airway infection …
with an unknown cause in around 30–40% of patients. The presence of airway infection …
Precision approaches to chronic obstructive pulmonary disease management
M Moll, EK Silverman - Annual Review of Medicine, 2024 - annualreviews.org
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …
worldwide. COPD heterogeneity has hampered progress in developing pharmacotherapies …
Crosstalk between epitranscriptomic and epigenomic modifications and its implication in human diseases
Crosstalk between N 6-methyladenosine (m 6 A) and epigenomes is crucial for gene
regulation, but its regulatory directionality and disease significance remain unclear. Here …
regulation, but its regulatory directionality and disease significance remain unclear. Here …
Associations of combined phenotypic ageing and genetic risk with incidence of chronic respiratory diseases in the UK Biobank: a prospective cohort study
T Wang, W Duan, X Jia, X Huang, Y Liu… - European …, 2024 - Eur Respiratory Soc
Background Accelerated biological ageing has been associated with an increased risk of
several chronic respiratory diseases. However, the associations between phenotypic age, a …
several chronic respiratory diseases. However, the associations between phenotypic age, a …
Does chronic obstructive pulmonary disease originate from different cell types?
The onset of chronic obstructive pulmonary disease (COPD) is heterogeneous, and current
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
approaches to define distinct disease phenotypes are lacking. In addition to clinical …
Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease
IR Konigsberg, T Vu, W Liu, EM Litkowski, KA Pratte… - BMC genomics, 2024 - Springer
Background Studies have identified individual blood biomarkers associated with chronic
obstructive pulmonary disease (COPD) and related phenotypes. However, complex …
obstructive pulmonary disease (COPD) and related phenotypes. However, complex …