Kinetoplastids: related protozoan pathogens, different diseases

K Stuart, R Brun, S Croft, A Fairlamb… - The Journal of …, 2008 - Am Soc Clin Investig
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma
and Leishmania, which are human pathogens with devastating health and economic effects …

Recent advances in trypanosomatid research: genome organization, expression, metabolism, taxonomy and evolution

DA Maslov, FR Opperdoes, AY Kostygov, H Hashimi… - Parasitology, 2019 - cambridge.org
Unicellular flagellates of the family Trypanosomatidae are obligatory parasites of
invertebrates, vertebrates and plants. Dixenous species are aetiological agents of a number …

Retooling Leishmania metabolism: from sand fly gut to human macrophage

D Rosenzweig, D Smith, F Opperdoes… - The FASEB …, 2008 - Wiley Online Library
To survive extremely different environments, intracellular parasites require highly adaptable
physiological and metabolic systems. Leishmania donovani extracellular promastigotes …

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

EC Saunders, WW Ng, J Kloehn, JM Chambers… - PLoS …, 2014 - journals.plos.org
Leishmania parasites alternate between extracellular promastigote stages in the insect
vector and an obligate intracellular amastigote stage that proliferates within the …

The Leishmania–macrophage interaction: a metabolic perspective

T Naderer, MJ McConville - Cellular microbiology, 2008 - Wiley Online Library
Protozoan parasites belonging to the genus Leishmania exhibit a pronounced tropism for
macrophages although they have the capacity to infect a variety of other phagocytic and non …

[HTML][HTML] Protein turnover and differentiation in Leishmania

S Besteiro, RAM Williams, GH Coombs… - International journal for …, 2007 - Elsevier
Leishmania occurs in several developmental forms and thus undergoes complex cell
differentiation events during its life-cycle. Those are required to allow the parasite to adapt to …

Leptomonas seymouri: adaptations to the dixenous life cycle analyzed by genome sequencing, transcriptome profiling and co-infection with Leishmania donovani

N Kraeva, A Butenko, J Hlaváčová, A Kostygov… - PLoS …, 2015 - journals.plos.org
The co-infection cases involving dixenous Leishmania spp.(mostly of the L. donovani
complex) and presumably monoxenous trypanosomatids in immunocompromised …

Metabolic Pathways Required for the Intracellular Survival of Leishmania

MJ McConville, T Naderer - Annual review of microbiology, 2011 - annualreviews.org
Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …

Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure

JCF Rodrigues, JLP Godinho, W De Souza - Proteins and Proteomics of …, 2013 - Springer
Leishmania and Trypanosoma belong to the Trypanosomatidae family and cause important
human infections such as leishmaniasis, Chagas disease, and sleeping sickness …

The uptake and metabolism of amino acids, and their unique role in the biology of pathogenic trypanosomatids

L Marchese, JF Nascimento, FS Damasceno… - Pathogens, 2018 - mdpi.com
Trypanosoma brucei, as well as Trypanosoma cruzi and more than 20 species of the genus
Leishmania, form a group of flagellated protists that threaten human health. These …