Developing novel targeted anticancer therapies is a major goal of current research. The use
of poly (ADP-ribose) polymerase (PARP) inhibitors in patients with homologous …

Immunotherapy has revolutionized the treatment of patients with cancer. However,
promoting antitumour immunity in patients with tumours that are resistant to these therapies …

Importance Ovarian cancer has the highest mortality rate among gynecologic malignant
tumors. Data are lacking on the survival benefit of hyperthermic intraperitoneal …

The therapeutic application of heat is very effective in cancer treatment. Both hyperthermia,
ie, heating to 39–45° C to induce sensitization to radiotherapy and chemotherapy, and …

Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures
to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer …

Recently, diverse functional materials that take subcellular structures as therapeutic targets
are playing increasingly important roles in cancer therapy. Here, particular emphasis is …

Hyperthermia, one of the oldest forms of cancer treatment involves selective heating of tumor
tissues to temperatures ranging between 39 and 45° C. Recent developments based on the …

Dysregulation of DNA damage repair and signalling to cell cycle checkpoints, known as the
DNA damage response (DDR), is associated with a predisposition to cancer and affects …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

The CRISPR/Cas9 system has greatly improved our ability to engineer targeted mutations in
eukaryotic genomes. While CRISPR/Cas9 appears to work universally, the efficiency of …