Summary The 2015 Magnetic Resonance Imaging in Multiple Sclerosis and 2016
Consortium of Multiple Sclerosis Centres guidelines on the use of MRI in diagnosis and …

Introduction In multiple sclerosis (MS), paramagnetic rim lesions (PRLs) on MRI identify a
subset of chronic active lesions (CALs), which have been linked through clinical and …

Recent data suggest that multiple sclerosis white matter lesions surrounded by a rim of iron
containing microglia, termed iron rim lesions, signify patients with more severe disease …

Background and Objectives Chronic active lesions contribute to multiple sclerosis (MS)
severity, but their association with long-term disease progression has not been evaluated …

Objective To assess whether chronic white matter inflammation in patients with multiple
sclerosis (MS) as detected in vivo by paramagnetic rim MRI lesions (PRLs) is associated …

Objective To determine the prognostic value of persisting neuroinflammation in multiple
sclerosis (MS) lesions, we developed a 18 kDa‐translocator‐protein‐positron emission …

Background: Paramagnetic rim lesions (PRLs) are an imaging biomarker in multiple
sclerosis (MS), associated with a more severe disease. Objectives: To determine …

Please see the Editorial Comment by Lei Wu discussing this article. To listen to the podcast
associated with this article, please select one of the following: iTunes, Google Play, or direct …

Chronic active lesions are promotors of neurodegeneration and disease progression in
multiple sclerosis. They harbour a dense rim of activated innate immune cells at the lesion …

Abstract Purpose of Review Multiple sclerosis is a chronic inflammatory disease of the
central nervous system. When seen in children and adolescents, crucial stages of brain …