Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

Endothelial cells (ECs) are vascular, nonconventional immune cells that play a major role in
the systemic response after bacterial infection to limit its dissemination. Triggered by …

Neonatal sepsis is the cause of substantial morbidity and mortality. Precise estimates of
neonatal sepsis burden vary by setting. Differing estimates of disease burden have been …

Aging is a major risk factor of high incidence and increased mortality of acute respiratory
distress syndrome (ARDS). Here, we demonstrated that persistent lung injury and high …

Fluid resuscitation is a core component of emergency and critical care medicine. While the
focus of clinicians has largely been on detecting patients who would respond to fluid …

Severe Sepsis and Septic Shock | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Circulating lactate levels are a critical biomarker for sepsis and are positively correlated with
sepsis-associated mortality. We investigated whether lactate plays a biological role in …

The endothelium provides an essential and selective membrane barrier that regulates the
movement of water, solutes, gases, macromolecules and the cellular elements of the blood …

Aggressive fluid resuscitation to achieve a central venous pressure (CVP) greater than 8 mm
Hg has been promoted as the standard of care, in the management of patients with severe …