Since the early 1980s, phosphodiesterase 4 (PDE4) has been an attractive target for the
treatment of inflammation-based diseases. Several scientific advancements, by both …

Conspectus One of the fundamental goals of chemists is to develop highly efficient methods
for producing optically active compounds, given their wide range of applications in …

Chemical manufacturing is conducted using either batch systems or continuous-flow
systems. Flow systems have several advantages over batch systems, particularly in terms of …

Bilateral olfactory bulbectomy results in changes in behavior, and in the endocrine, immune
and neurotransmitter systems, that simulates many of those seen in patients with major …

Activation of the immune system produces psychological and physiological effects, which
resemble the characteristics of depression. The present study was designed to investigate …

Nitric oxide (NO) is a free radical found at higher than normal concentrations within
inflammatory multiple sclerosis (MS) lesions. These high concentrations are due to the …

The concept of flow “fine” synthesis, that is, high yielding and selective organic synthesis by
flow methods, is described. Some examples of flow “fine” synthesis of natural products and …

Microglia are a major glial component of the central nervous system (CNS) and are
extremely sessile. Only a subtype, the perivascular microglia, are regularly replaced from the …

Traditionally, both stress and depression have been associated with impaired immune
function and increased susceptibility to infectious and neoplastic disease. However over the …

There is now some evidence that major depression is accompanied by activation of the
inflammatory response system. There is also some evidence that antidepressants may …