In arbitrary dimension, in the discrete setting of finite-differences we prove a Carleman
estimate for a semi-discrete parabolic operator, in which the large parameter is connected to …

In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …

Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

Bile acids and their signaling pathways are increasingly recognized as potential therapeutic
targets for cholestatic and metabolic liver diseases. This review summarizes new insights in …

Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were
outwardly identical to wild-type littermates. FXR/BAR null mice were distinguished from wild …

The family of bile acids includes a group of molecular species of acidic steroids with very
peculiar physical-chemical and biological characteristics. They are synthesized by the liver …

Molecular medicine has led to rapid advances in the characterization of hepatobiliary
transport systems that determine the uptake and excretion of bile salts and other biliary …

Progressive familial intrahepatic cholestasis (PFIC) is a group of rare disorders which are
caused by defect in bile secretion and present with intrahepatic cholestasis, usually in …

The vectorial transport of bile salts from blood into bile is essential for the generation of bile
flow, solubilization of cholesterol in bile, and emulsification of lipids in the intestine. Major …

Specific transporters expressed in the liver and the intestine, play a critical role in driving the
enterohepatic circulation of bile acids. By preserving a circulating pool of bile acids, an …