Abstract Human carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are serine
esterases responsible for the hydrolysis of ester and amide bonds present in a number of …

Small molecules that can selectively target cancer stem cells (CSCs) remain rare currently
and exhibit no common structural features. Here we report a series of guaianolide …

Doxorubicin has been in use as a key anticancer drug for forty years, either as a single
agent or in combination chemotherapy. It functions primarily by interfering with …

Carboxylesterase 2 (CES 2) is a key enzyme in the activation of the prodrug irinotecan (CPT-
11) in the treatment against colorectal cancer and also has some relationship with the side …

Irinotecan-based therapy is a common treatment for pancreatic cancer. To elicit its
anticancer activity, the drug requires first the hydrolysis action of the enzyme human …

The cytotoxicity of doxorubicin, a clinically used anti-neoplastic drug, can be enhanced by
formaldehyde (either endogenous or exogenous) to promote the formation of doxorubicin …

Colloidal drug aggregates have been a nuisance in drug screening, yet, because they
inherently comprise drug-rich particles, they may be useful in vivo if issues of stability can be …

Orlistat has been the most used anti-obesity drug and the mechanism of its action is to
reduce lipid absorption by inhibiting gastrointestinal lipases. These enzymes, like …

Doxazolidine (doxaz) is a new anthracycline anticancer agent. While structurally similar to
doxorubicin (dox), doxaz acts via a distinct mechanism to selectively enhance anticancer …

Near-infrared (NIR) fluorescent probes have excellent properties such as fast imaging
speed, non-invasive, good stability and low background interference, and have great …