Tryptophan metabolism as a pharmacological target
M Modoux, N Rolhion, S Mani, H Sokol - Trends in pharmacological …, 2021 - cell.com
L-Tryptophan is an essential amino acid required for protein synthesis. It undergoes an
extensive and complex metabolism along several pathways, resulting in many bioactive …
extensive and complex metabolism along several pathways, resulting in many bioactive …
The role of dissociation in ketamine's antidepressant effects
ED Ballard, CA Zarate Jr - Nature communications, 2020 - nature.com
Ketamine produces immediate antidepressant effects and has inspired research into next-
generation treatments. Ketamine also has short term dissociative effects, in which …
generation treatments. Ketamine also has short term dissociative effects, in which …
Novel glutamatergic modulators for the treatment of mood disorders: current status
The efficacy of standard antidepressants is limited for many patients with mood disorders
such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent …
such as major depressive disorder (MDD) and bipolar depression, underscoring the urgent …
NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites
Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …
bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the …
Aiding and abetting anhedonia: impact of inflammation on the brain and pharmacological implications
Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
chronic endogenous inflammatory states lead to motivational deficits and ultimately …
[HTML][HTML] Kynurenine pathway of tryptophan metabolism in neuropsychiatric disorders: pathophysiologic and therapeutic considerations
A Muneer - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Under physiological conditions 95% of the ingested essential amino acid tryptophan is
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
metabolized by the kynurenine pathway (KP) to yield the ubiquitous co-enzyme …
NMDA receptors as therapeutic targets for depression treatment: Evidence from clinical to basic research
S Lv, K Yao, Y Zhang, S Zhu - Neuropharmacology, 2023 - Elsevier
Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …
Sex-and suicide-specific alterations in the kynurenine pathway in the anterior cingulate cortex in major depression
SJ Brown, K Christofides, C Weissleder… - …, 2024 - nature.com
Major depressive disorder (MDD) is a serious psychiatric disorder that in extreme cases can
lead to suicide. Evidence suggests that alterations in the kynurenine pathway (KP) …
lead to suicide. Evidence suggests that alterations in the kynurenine pathway (KP) …
Novel rapid-acting glutamatergic modulators: targeting the synaptic plasticity in depression
YT Wang, XL Wang, ST Feng, NH Chen… - Pharmacological …, 2021 - Elsevier
Major depressive disorder (MDD) is severely prevalent, and conventional monoaminergic
antidepressants gradually exhibit low therapeutic efficiency, especially for patients with …
antidepressants gradually exhibit low therapeutic efficiency, especially for patients with …