Genetic variants, including single-nucleotide variants (SNVs) and copy number variants
(CNVs), in the non-coding regions of the human genome can play an important role in …

Thousands of genes encoding long noncoding RNAs (lncRNAs) have been identified in all
vertebrate genomes thus far examined. The list of lncRNAs partaking in arguably important …

Circular RNAs are new players in regulation of post transcriptional gene expression. Animal
genomes express many circular RNAs from diverse genomic locations. A recent study has …

Genome-wide association studies (GWAS) have proven a fundamental tool to identify
common variants associated to complex traits, thus contributing to unveil the genetic …

Uncorrected obesity has been associated with cardiac hypertrophy and contractile
dysfunction. Several mechanisms for this cardiomyopathy have been identified, including …

The last decade has seen tremendous improvements in the understanding of human
variations and their association with human traits and diseases. The availability of high …

MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two crucial classes of
transcripts that belong to the major group of non-coding RNAs (ncRNAs). These RNA …

In the last decade, it has been demonstrated that long non-coding RNAs (lncRNAs) are
involved in cancer development. The great majority of studies on lncRNAs report alterations …

Understanding the genetic basis of human traits/diseases and the underlying mechanisms
of how these traits/diseases are affected by genetic variations is critical for public health …

This is the first of 2 review papers on genetics and genomics appearing as part of the series
on “omics.” Genomics pertains to all components of an organism's genes, whereas genetics …