Astrocytes are the most abundant glial cell type in the central nervous system and are
essential to the development, plasticity, and maintenance of neural circuits. Astrocytes are …

During embryonic brain development, neurogenesis requires the orchestration of gene
expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with …

The neocortex is considered the seat of higher cognitive function in humans. It develops
from a sheet of neural progenitor cells, most of which eventually give rise to neurons. This …

Neural progenitor cells undergo identity transitions during development to ensure the
generation different types of neurons and glia in the correct sequence and proportions. A …

The nervous system consists of several hundred neuronal subtypes and glial cells that show
specific gene expression and are generated from common ancestors, neural stem cells …

Stem cells that indirectly generate differentiated cells through intermediate progenitors
drives vertebrate brain evolution. Due to a lack of lineage information, how stem cell …

Recent studies have demonstrated that epigenetic modifications are deeply involved in
neurogenesis; however, the precise mechanisms remain largely unknown. To determine the …

How neurons can maintain cellular identity over an entire life span remains largely
unknown. Here, we show that maintenance of identity in differentiated dopaminergic and …

RYBP (Ring1 and YY1 binding protein), an essential component of the Polycomb repressive
complex 1 (PRC1), plays pivotal roles in development and diseases. However, the roles of …

Intermediate progenitors (IPs)–sometimes called basal progenitors–are molecularly and
morphologically distinct cortical progenitor cells, committed to genesis of glutamatergic …