Melanoma, a skin cancer associated with high mortality rates, is highly radio-and
chemotherapy resistant but can also be very immunogenic. These circumstances have led to …

Cancer is currently the second leading cause of death globally and is expected to be
responsible for approximately 9.6 million deaths in 2018. With an unprecedented …

T cells are an essential part of the immune system with crucial roles in adaptive response
and the maintenance of tissue homeostasis. Depending on their microenvironment, T cells …

The immune system is involved in the initiation and progression of cancer. Research on
cancer and immunity has contributed to the development of several clinically successful …

Melanoma is the most lethal form of skin cancer. Melanoma is usually curable with surgery if
detected early, however, treatment options for patients with metastatic melanoma are limited …

There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …

Recent success of immunotherapy strategies such as immune checkpoint blockade in
several malignancies has established the role of immunotherapy in the treatment of cancer …

The therapeutic efficacy of current cancer vaccines is far from optimal, mainly because of
insufficient induction of antigen-specific T cells and because tumor cells can hijack …

Ipilimumab has revolutionized malignant melanoma therapy, but a better understanding of
the mechanisms behind treatment response and adverse effects is needed. In this work, the …

Immunotherapy in colorectal cancer (CRC) has made great strides within the past decade.
Immune checkpoint inhibitors are a class of immunotherapy and have been shown to greatly …