Target DNA-dependent activation mechanism of the prokaryotic immune system SPARTA
G Finocchio, B Koopal, A Potocnik… - Nucleic acids …, 2024 - academic.oup.com
In both prokaryotic and eukaryotic innate immune systems, TIR domains function as
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
NADases that degrade the key metabolite NAD+ or generate signaling molecules. Catalytic …
Insights into the modulation of bacterial NADase activity by phage proteins
H Yin, X Li, X Wang, C Zhang, J Gao, G Yu… - Nature …, 2024 - nature.com
Abstract The Silent Information Regulator 2 (SIR2) protein is widely implicated in antiviral
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …
response by depleting the cellular metabolite NAD+. The defense-associated sirtuin 2 …
Structural basis of antiphage immunity generated by a prokaryotic Argonaute-associated SPARSA system
X Zhen, X Xu, L Ye, S Xie, Z Huang, S Yang… - Nature …, 2024 - nature.com
Argonaute (Ago) proteins are ubiquitous across all kingdoms of life. Eukaryotic Agos
(eAgos) use small RNAs to recognize transcripts for RNA silencing in eukaryotes. In …
(eAgos) use small RNAs to recognize transcripts for RNA silencing in eukaryotes. In …