The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in
all human tissues. It is comprised of varying proteins, including collagens, elastin, and …

The complement system is an important part of the innate immune defence. It contributes not
only to local inflammation, removal and killing of pathogens, but it also assists in shaping of …

Here, using single-cell RNA sequencing, we examine the stromal compartment in murine
melanoma and draining lymph nodes (LNs) at points across tumor development, providing …

The complement system is deeply embedded in our physiology and immunity. Complement
activation generates a multitude of molecules that converge simultaneously on the …

The complement system plays a crucial role in the innate defense against common
pathogens. Activation of complement leads to robust and efficient proteolytic cascades …

The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-
inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to …

The complement activation product C3a is often described as a proinflammatory mediator,
alongside its downstream cousin, C5a. However, emerging studies show that C3a has …

Excessive activation of blood coagulation and neutrophil accumulation have been described
in several human cancers. However, whether hypercoagulation and neutrophilia are linked …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

Mammalian phagocytes can phagocytose (ie eat) other mammalian cells in the body if they
display certain signals, and this phagocytosis plays fundamental roles in development, cell …