The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

Filament formation by non-cytoskeletal enzymes has been known for decades, yet only
relatively recently has its wide-spread role in enzyme regulation and biology come to be …

Pattern recognition and classification of images are key challenges throughout the life
sciences. We combined two approaches for large-scale classification of fluorescence …

The universally conserved enzyme CTP synthase (CTPS) forms filaments in bacteria and
eukaryotes. In bacteria, polymerization inhibits CTPS activity and is required for nucleotide …

Results of the anti-nuclear antibodies-indirect immunofluorescence assay (anti-cell
antibodies test) on HEp-2 cell substrates should be communicated to clinicians in a …

BCL6, an oncogenic transcription factor (TF), forms polymers in the presence of a small-
molecule molecular glue that stabilizes a complementary interface between homodimers of …

The purine nucleotides ATP and GTP are essential precursors to DNA and RNA synthesis
and fundamental for energy metabolism. Although de novo purine nucleotide biosynthesis is …

The organization of metabolic multienzyme complexes has been hypothesized to benefit
metabolic processes and provide a coordinated way for the cell to regulate metabolism …

Inosine monophosphate dehydrogenase (IMPDH) mediates the first committed step in
guanine nucleotide biosynthesis and plays important roles in cellular proliferation and the …

Abstract Inosine-5′-monophosphate dehydrogenase (IMPDH), a key regulatory enzyme in
purine nucleotide biosynthesis, dynamically assembles filaments in response to changes in …