The emerging role of SARS-CoV-2 nonstructural protein 1 (nsp1) in epigenetic regulation of host gene expression
KI Ivanov, H Yang, R Sun, C Li… - FEMS Microbiology …, 2024 - academic.oup.com
Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes
widespread changes in epigenetic modifications and chromatin architecture in the host cell …
widespread changes in epigenetic modifications and chromatin architecture in the host cell …
[HTML][HTML] Identification of SARS-CoV-2 m6A modification sites correlate with viral pathogenicity
K Liu, YZ Zhang, H Yin, LL Yu, JJ Cui, JY Yin… - Microbes and …, 2024 - Elsevier
It has recently been found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) m6A modifications can affect viral replication and function. However, no studies to date …
2) m6A modifications can affect viral replication and function. However, no studies to date …
Automated single-cell omics end-to-end framework with data-driven batch inference
To facilitate single-cell multi-omics analysis and improve reproducibility, we present single-
cell pipeline for end-to-end data integration (SPEEDI), a fully automated end-to-end …
cell pipeline for end-to-end data integration (SPEEDI), a fully automated end-to-end …
Chikungunya patient transcriptional signatures faithfully recapitulated in a C57BL/6J mouse model
Introduction An adult wild-type C57BL/6J mouse model of chikungunya virus (CHIKV)
infection and disease has been extensively used to study the alphaviral arthritic …
infection and disease has been extensively used to study the alphaviral arthritic …
Multi-objective optimization identifies a specific and interpretable COVID-19 host response signature
The identification of a COVID-19 host response signature in blood can increase the
understanding of SARS-CoV-2 pathogenesis and improve diagnostic tools. Applying a multi …
understanding of SARS-CoV-2 pathogenesis and improve diagnostic tools. Applying a multi …
Identification of cell subpopulations associated with disease phenotypes from scRNA-seq data using PACSI
Background Single-cell RNA sequencing (scRNA-seq) has revolutionized the
transcriptomics field by advancing analyses from tissue-level to cell-level resolution. Despite …
transcriptomics field by advancing analyses from tissue-level to cell-level resolution. Despite …
ATAC-clock: An aging clock based on chromatin accessibility
The establishment of aging clocks highlighted the strong link between changes in DNA
methylation and aging. Yet, it is not known if other epigenetic features could be used to …
methylation and aging. Yet, it is not known if other epigenetic features could be used to …
Dynamics of cytokine and antibody responses in community versus hospital SARS-CoV-2 infections
T Singh, AN Macintyre, TW Burke, J Anderson… - Frontiers in …, 2024 - frontiersin.org
Introduction Dysregulated host cytokine responses to SARS-CoV-2 infection are a primary
cause of progression to severe disease, whereas early neutralizing antibody responses are …
cause of progression to severe disease, whereas early neutralizing antibody responses are …
The Role of Changes in Structure and Dynamics of Chromatin due to COVID-19
AE Bigildeev, VI Alekseev, AK Gribkova… - Russian Journal of …, 2024 - Springer
The COVID-19 pandemic has become a serious challenge for the healthcare system and the
economy of many states, and understanding the molecular mechanisms of the pathogenesis …
economy of many states, and understanding the molecular mechanisms of the pathogenesis …
Remodeling of the chromatin landscape in peripheral blood cells in patients with severe Delta COVID-19
VE Akimov, DI Tychinin, OA Antonova… - Frontiers in …, 2024 - frontiersin.org
COVID-19 is characterized by systemic pro-inflammatory shifts with the development of
serious alterations in the functioning of the immune system. Investigations of the gene …
serious alterations in the functioning of the immune system. Investigations of the gene …