Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness,
has been proposed as a mechanism driving directed migration. Despite the lack of evidence …

INTRODUCTION Cells migrate over long distances during normal embryonic development
and in disease, and they navigate through complex, branched paths. Chemotaxis, cell …

Durotaxis is a type of directed cell migration in which cells respond to a gradient of
extracellular stiffness. Using automated tracking of positional data for large sample sizes of …

Cancer metastasis requires the invasion of tumor cells into the stroma and the directed
migration of tumor cells through the stroma toward the vasculature and lymphatics where …

Breakdown of vascular barriers is a major complication of inflammatory diseases. Anucleate
platelets form blood-clots during thrombosis, but also play a crucial role in inflammation …

Cancer cell invasion through physical barriers in the extracellular matrix (ECM) requires a
complex synergy of traction force against the ECM, mechanosensitive feedback, and …

Directed migration of cells through cell–surface interactions is a paramount prerequisite in
biomaterial-induced tissue regeneration. However, whether and how the nanoscale spatial …

Hyperinflammation plays an important role in severe and critical COVID-19. Using
inconsistent criteria, many researchers define hyperinflammation as a form of very severe …

Actin-based protrusions are reinforced through positive feedback, but it is unclear what
restricts their size, or limits positive signals when they retract or split. We identify an …