Vaccines and first-generation antiviral therapeutics have provided important protection
against COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV …

Summary The coronavirus disease 2019 (COVID-19), the disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents the most disastrous …

Nirmatrelvir (PF-07321332), a first-in-class inhibitor of the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) main protease (Mpro), was developed by Pfizer …

The RNA-dependent RNA polymerase (RdRp), 3C-like protease (3CLpro), and papain-like
protease (PLpro) are pivotal components in the viral life cycle of SARS-CoV-2, presenting as …

The unique and complex structure of papain-like protease (PL pro) of the SARS-CoV-2 virus
represents a difficult challenge for antiviral development, yet it offers a compelling validated …

The COVID-19 pandemic-led worldwide healthcare crisis necessitates prompt societal,
ecological, and medical efforts to stop or reduce the rising number of fatalities. Numerous …

The COVID-19 pandemic, exacerbated by persistent viral mutations, underscored the urgent
need for diverse inhibitors targeting multiple viral proteins. In this study, we utilized covalent …

A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications
in cells, allowing the evasion of antiviral immune response mechanisms. In this study …

The COVID-19 pandemic is caused by SARS-CoV-2, a highly transmissible and pathogenic
RNA betacoronavirus. Like other RNA viruses, SARS-CoV-2 continues to evolve with or …

The COVID-19 pandemic, instigated by the emergence of the novel coronavirus, SARS-CoV-
2, created an incomparable global health crisis. Due to its highly virulent nature, identifying …