[HTML][HTML] Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
YL Wu, ZJ Lin, CC Li, X Lin, SK Shan, B Guo… - … and Targeted Therapy, 2023 - nature.com
Epigenetics regulates gene expression and has been confirmed to play a critical role in a
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration
L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …
[HTML][HTML] Epigenetics in human obesity and type 2 diabetes
Epigenetic mechanisms control gene activity and the development of an organism. The
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
epigenome includes DNA methylation, histone modifications, and RNA-mediated processes …
The ageing epigenome and its rejuvenation
Ageing is characterized by the functional decline of tissues and organs and the increased
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
risk of ageing-associated disorders. Several 'rejuvenating'interventions have been proposed …
[HTML][HTML] The hexosamine biosynthesis pathway: regulation and function
A Paneque, H Fortus, J Zheng, G Werlen, E Jacinto - Genes, 2023 - mdpi.com
The hexosamine biosynthesis pathway (HBP) produces uridine diphosphate-N-acetyl
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
glucosamine, UDP-GlcNAc, which is a key metabolite that is used for N-or O-linked …
Epigenetics of type 2 diabetes mellitus and weight change—a tool for precision medicine?
Pioneering studies performed over the past few decades demonstrate links between
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
epigenetics and type 2 diabetes mellitus (T2DM), the metabolic disorder with the most …
[HTML][HTML] The emerging role of epigenetics in human autoimmune disorders
Epigenetic pathways play a pivotal role in the development and function of the immune
system. Over the last decade, a growing body of studies has been published out seeking to …
system. Over the last decade, a growing body of studies has been published out seeking to …
[HTML][HTML] Caloric restriction delays age-related methylation drift
In mammals, caloric restriction consistently results in extended lifespan. Epigenetic
information encoded by DNA methylation is tightly regulated, but shows a striking drift …
information encoded by DNA methylation is tightly regulated, but shows a striking drift …
Epigenetic modification of nucleic acids: from basic studies to medical applications
The epigenetic modification of nucleic acids represents one of the most significant areas of
study in the field of nucleic acids because it makes gene regulation more complex and …
study in the field of nucleic acids because it makes gene regulation more complex and …