Converging evidence implicates redox dysregulation as a pathological mechanism driving
the emergence of psychosis. Increased oxidative damage and decreased capacity of …

What have we accomplished for schizophrenia patients since the introduction of
chlorpromazine in 1952 (1)? Have we really made a difference in the outcome of …

Importance Altered neurodevelopmental trajectories are thought to reflect heterogeneity in
the pathophysiologic characteristics of schizophrenia, but whether neural indicators of these …

Background: Several cross-sectional studies report brain structure differences between
healthy volunteers and subjects at genetic or clinical high risk of developing schizophrenia …

To date, a large number of magnetic resonance imaging (MRI) studies have been conducted
in schizophrenia, which generally demonstrate gray matter reduction, predominantly in the …

Abstract Study Objectives Structural brain maturation and sleep are complex processes that
exhibit significant changes over adolescence and are linked to many physical and mental …

Adolescence is a period of increased vulnerability for the development of psychiatric
disorders, including schizophrenia. The prefrontal cortex (PFC) undergoes substantial …

Preterm birth is associated with an elevated risk of developmental and adult psychiatric
disorders, including psychosis. In this review, we evaluate the implications of …

Background Increased expression of the complement component 4A (C4A) gene is
associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in …

Cognitive functions including social cognition improve significantly during adolescence, the
time period during which the brain typically handles a large volume of incoming information …