Targeted alpha therapy: current clinical applications

FDC Guerra Liberal, JM O'Sullivan… - Cancer biotherapy & …, 2020 - liebertpub.com
α-Emitting radionuclides have been approved for cancer treatment since 2013, with
increasing degrees of success. Despite this clinical utility, little is known regarding the …

[HTML][HTML] Therapeutic radionuclides in nuclear medicine: current and future prospects

CH Yeong, M Cheng, KH Ng - Journal of Zhejiang University …, 2014 - ncbi.nlm.nih.gov
The potential use of radionuclides in therapy has been recognized for many decades. A
number of radionuclides, such as iodine-131 (131 I), phosphorous-32 (32 P), strontium-90 …

The potential and hurdles of targeted alpha therapy–clinical trials and beyond

J Elgqvist, S Frost, JP Pouget, P Albertsson - Frontiers in oncology, 2014 - frontiersin.org
This article presents a general discussion on what has been achieved so far and on the
possible future developments of targeted alpha (α)-particle therapy (TAT). Clinical …

The chemical scaffold of theranostic radiopharmaceuticals: radionuclide, bifunctional chelator, and pharmacokinetics modifying linker

HA Holik, FM Ibrahim, AA Elaine, BD Putra, A Achmad… - Molecules, 2022 - mdpi.com
Therapeutic radiopharmaceuticals have been researched extensively in the last decade as
a result of the growing research interest in personalized medicine to improve diagnostic …

Peptide receptor radionuclide therapy: an overview

A Dash, S Chakraborty, MRA Pillai… - Cancer Biotherapy and …, 2015 - liebertpub.com
Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy
that specifically uses radiolabeled peptides as biological targeting vectors designed to …

Targeted radionuclide therapy-an overview

A Dash, F F.(Russ) Knapp… - Current …, 2013 - benthamdirect.com
Radionuclide therapy (RNT) based on the concept of delivering cytotoxic levels of radiation
to disease sites is one of the rapidly growing fields of nuclear medicine. Unlike conventional …

Peptide receptor radionuclide therapy of neuroendocrine tumors

S Basu, RV Parghane, S Chakrabarty - Seminars in Nuclear Medicine, 2020 - Elsevier
Peptide receptor radionuclide therapy (PRRT), over the years, has evolved as an important
modality in the therapeutic armamentarium of advanced, metastatic or inoperable …

Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131I for Single Photon Emission Computed Tomography Imaging and Radiotherapy …

L Zhao, J Zhu, Y Cheng, Z Xiong, Y Tang… - … Applied Materials & …, 2015 - ACS Publications
Chlorotoxin-conjugated multifunctional dendrimers labeled with radionuclide 131I were
synthesized and utilized for targeted single photon emission computed tomography …

Radiolabeled enzyme inhibitors and binding agents targeting PSMA: effective theranostic tools for imaging and therapy of prostate cancer

MRA Pillai, R Nanabala, A Joy, A Sasikumar… - Nuclear medicine and …, 2016 - Elsevier
Because of the broad incidence, morbidity and mortality associated with prostate-derived
cancer, the development of more effective new technologies continues to be an important …

Cutting edge rare earth radiometals: prospects for cancer theranostics

AWE Sadler, L Hogan, B Fraser… - EJNMMI Radiopharmacy …, 2022 - Springer
Background With recent advances in novel approaches to cancer therapy and imaging, the
application of theranostic techniques in personalised medicine has emerged as a very …