New types of antidiabetic agents are continually needed with diabetes becoming the
epidemic in the world. Indole alkaloids play an important role in natural products owing to …

Metabolic syndrome (MS) remains one of the leading causes of mortality in Western
societies and has become a major public health challenge worldwide. 1 The term metabolic …

Binding to helix 12 of the ligand-binding domain of PPARγ is required for full agonist activity.
Previously, the degree of stabilization of the activation function 2 (AF-2) surface was thought …

A series of new benzothiazole-1, 3, 4-oxadiazole-4-thiazolidinone hybrid analogs (Tz1-
Tz28) were synthesized in search of potential anti-diabetic agents. Molecular docking study …

The nuclear receptor, peroxisome proliferator‐activated receptor γ (PPARγ), recognizes
various synthetic and endogenous ligands by the ligand‐binding domain. Fatty‐acid …

Patients with type-2 diabetes mellitus (T2DM) are considered to be at particularly high risk
for cardiovascular disease. Over the last decade, the members of the peroxisome proliferator …

Abstract Di-2-ethylhexyl phthalate (DEHP) and its substitute 1, 2-cyclohexane dicarboxylic
acid diisononyl ester (DINCH) are widely used as plasticizers but may have adverse health …

Obesity is an abnormal fat accumulation disorder in the metabolic syndrome constellation,
and a risk factor for diabetes, cardiovascular disorders, non-alcoholic fatty liver disease …

Peroxisome proliferator-activated receptor gamma (PPARγ) and sulfonylurea receptor
(SUR) play crucial roles in management of type-2 diabetes mellitus. In this study, a series of …

Nitrogen containing heterocyclic rings with an oxygen atom is considered as one of the best
combination in medicinal chemistry due to their diversified biological activities. Isoxazole, a …