Microbial Peptidyl-Prolyl cis/trans Isomerases (PPIases): Virulence Factors and Potential Alternative Drug Targets

CM Ünal, M Steinert - Microbiology and molecular biology reviews, 2014 - Am Soc Microbiol
Initially discovered in the context of immunomodulation, peptidyl-prolyl cis/trans isomerases
(PPIases) were soon identified as enzymes catalyzing the rate-limiting protein folding step at …

A druggable secretory protein maturase of Toxoplasma essential for invasion and egress

SK Dogga, B Mukherjee, D Jacot, T Kockmann… - Elife, 2017 - elifesciences.org
Micronemes and rhoptries are specialized secretory organelles that deploy their contents at
the apical tip of apicomplexan parasites in a regulated manner. The secretory proteins …

Research advances in interactions related to Toxoplasma gondii microneme proteins

Q Liu, FC Li, CX Zhou, XQ Zhu - Experimental parasitology, 2017 - Elsevier
Toxoplasma gondii microneme proteins (TgMICs), secreted by micronemes upon contact
with host cells, are reported to play important roles in multiple stages of the T. gondii life …

Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain

S Mukherjee, AS Nasamu, KC Rubiano, DE Goldberg - Mbio, 2023 - Am Soc Microbiol
Following each round of replication, daughter merozoites of the malaria parasite
Plasmodium falciparum escape (egress) from the infected host red blood cell (RBC) by …

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin

C Withers-Martinez, M Strath, F Hackett… - Nature …, 2014 - nature.com
Malaria is caused by a protozoan parasite that replicates within an intraerythrocytic
parasitophorous vacuole. Release (egress) of malaria merozoites from the host erythrocyte …

Maturation of subtilisin-like protease NbSLP1 from microsporidia Nosema bombycis

R Wang, Q Li, F Liu, X Dang, Q Sun… - Frontiers in Cellular …, 2022 - frontiersin.org
Microsporidia are obligate intracellular parasites and possess a unique way of invading
hosts, namely germination. Microsporidia are able to infect almost all animal cells by …

[PDF][PDF] Review on diagnosis and molecular characterization of Toxoplasma gondii in humans and animals.

A Uddin, D Hossain, MI Ahsan, M Atikuzzaman… - 2021 - researchgate.net
Toxoplasma gondii is an obligate intracellular protozoon which causes toxoplasmosis, an
important zoonotic disease that is endemic worldwide. Common sources of T. gondii …

Identification and Molecular Characterization of Microneme 5 of Eimeria acervulina

ZC Zhang, JW Huang, MH Li, YX Sui, S Wang, LR Liu… - PLoS …, 2014 - journals.plos.org
In the present study, the microneme 5 gene of Eimeria acervulina (E. acervulina)(EaMIC5)
was cloned and characterized. Specific primers for the rapid amplification of cDNA ends …

An ortholog of Plasmodium falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in …

LB Thornton, P Teehan, K Floyd, C Cochrane… - PLoS …, 2019 - journals.plos.org
Toxoplasma gondii is an apicomplexan parasite with the ability to use foodborne, zoonotic,
and congenital routes of transmission that causes severe disease in immunocompromised …

Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress

M Martinez, A Bouillon, S Brûlé, B Raynal, A Haouz… - Mbio, 2024 - Am Soc Microbiol
Malaria symptoms are associated with the asexual multiplication of Plasmodium falciparum
within human red blood cells (RBCs) and fever peaks coincide with the egress of daughter …